Menene sinadarin Shikimic Acid?

Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) wani sinadari ne na halitta wanda ke da mahimmanci a cikin biosynthesis na lignin, amino acid masu ƙanshi (phenylalanine, tyrosine da tryptophan), da yawancin alkaloids na tsire-tsire da ƙwayoyin cuta.

Ana amfani da sinadarin Shikimic acid a matsayin abin da ake amfani da shi wajen haɗa maganin rigakafi na oseltamivir (wani maganin cutar mura ta H5N1 da ake amfani da shi wajen magancewa da kuma hana dukkan nau'ikan ƙwayoyin cuta na mura da aka sani). An ruwaito cewa ana amfani da sinadarin (-)-zeylenone bisa ga Shikimic Acid sosai a matsayin maganin cutar kansa. Ana samun bayanai kan haɗa sinadarin monopalmitoyloxy Shikimic Acid, wanda ke da aikin hana zubar jini kuma yana iya rage yawan zubar jini idan aka yi amfani da shi ta hanyar jijiya. Wata ƙungiyar bincike ta ƙasar Sin ta haɗa wani sinadari mai suna Shikimic Acid, triacetyl Shikimic Acid, wanda ke nuna aikin hana zubar jini da kuma hana zubar jini.

Bugu da ƙari, abubuwan da aka samo daga Shikimic Acid sun nuna sha'awar noma sosai domin da yawa daga cikinsu ana amfani da su azaman maganin kashe kwari da magungunan kashe ƙwayoyin cuta saboda suna iya toshe hanyar Shikimic Acid a cikin tsirrai da ƙwayoyin cuta ba tare da yin mummunan tasiri ga dabbobi masu shayarwa ba.

Saboda haka, ana iya amfani da Shikimic Acid a matsayin mai amsawa ga haɗakar kwayoyin halitta a cikin ilimin kimiyya na asali da aikace-aikacen likita a cikin ilmin sunadarai na kwayoyin halitta da magani, musamman don shirya magunguna daban-daban.

A matsayin muhimmin abu na sinadarai na magunguna, ana iya amfani da shi shikimic acid don magance cututtuka da yawa:

1. Maganin ƙwayoyin cuta da kuma maganin ƙari

A shekarar 1987, masana kimiyyar Japan sun gano cewa analog na maganin hana glyoxalase I wanda methyl anthranilate ya samar yana da tasiri mai kyau akan layin ƙwayoyin Hela da cutar kansa ta Escheri ascites, yana iya tsawaita lokacin rayuwa na beraye da aka yi wa allurar ƙwayar cutar sankarar bargo L1210, kuma gubar ba ta da yawa, tasirin hana shi galibi yana da alaƙa da amsawar sulfur hydride. A shekarar 1988, masana kimiyyar Sin sun yi A shekarar 1988, masana kimiyyar Sin sun yi wani sinadari mai suna shikimic acid kuma sun tabbatar da cewa wannan sinadari yana da tasirin hana ƙwayoyin cutar sankarar bargo L1210 a cikin vitro.

2. Maganin thrombosis

Tasirin shikimic acid da abubuwan da ya samo asali a kan tsarin zuciya da jijiyoyin jini an nuna su a cikin rawar da yake takawa wajen hana thrombosis da kuma hana tarin platelets. Bincike ya nuna cewa: shikimic acid yana da tasiri mai ƙarfi akan yawan tarin platelets na beraye masu kama da adenosine diphosphate waɗanda ke haifar da embolism na tsakiyar jijiyoyin kwakwalwa; allurar shikimic acid ta jijiya da ta cikin jijiya na iya sa beraye su daɗe suna zubar jini.

3. Maganin ischemia na kwakwalwa

Shikimic acid da abubuwan da ya samo asali suna da tasirin inganta ischemia na kwakwalwa, musamman wajen rage yawan bugun zuciya bayan bugun zuciya mai tsanani a cikin beraye, rage yawan aikin jijiyoyi, rage matakin kumburin kwakwalwa, ƙara yawan kwararar jinin kwakwalwa a yankin ischemic da sauran alamu. Wasu bincike sun nuna cewa abubuwan da ya samo asali na iya rage matakin tarin erythrocyte da kuma hana tarin platelets bayan bugun zuciya, don haka yana sauƙaƙa microcirculation na kwakwalwa.