Menene Shikimic Acid?

Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) wani nau'in halitta ne wanda ke faruwa ta halitta wanda shine muhimmin matsakaici a cikin biosynthesis na lignin, amino acid na aromatic (phenylalanine, tyrosine da tryptophan), da galibi shuke-shuke da microbial alkaloids.

Shikimic acid ana yawan amfani dashi azaman kayan farawa don haɗakar masana'antu na maganin ƙwayar cuta oseltamivir (maganin rigakafin H5N1 da ake amfani da shi don magancewa da hana duk sanannun nau'ikan ƙwayoyin cuta na mura). Haɗin (-) zeylenone dangane da Shikimic Acid an ba da rahoton cewa ana amfani da shi sosai azaman wakili don maganin cutar kansa. Ana samun bayanai game da haɗin monopalmitoyloxy Shikimic Acid, wanda ke da aikin rigakafin jijiyar jini kuma yana da ikon rage coagulability na jini lokacin gudanar da shi ta cikin tsoka. Tawagar bincike ta kasar Sin ta hada wani sinadarin Shikimic Acid, triacetyl Shikimic Acid, wanda ke baje kolin maganin jijiyoyi da aikin antithrombotic.

Bugu da kari, abubuwan da ake samu na Shikimic Acid sun nuna matukar sha’awar noma domin yawancinsu ana amfani da su azaman maganin ciyawa da maganin kashe kwayoyin cuta domin suna iya toshe hanyar Shikimic Acid a cikin tsirrai da kwayoyin cuta ba tare da cutar da dabbobi masu shayarwa ba.

Don haka, ana iya amfani da Shikimic Acid azaman mai amsawa don haɗakar da kwayoyin halitta a cikin kimiyyar asali da aikace-aikacen likitanci a cikin sinadarai da magunguna, musamman don shirye-shiryen magunguna daban-daban.

A matsayin muhimmin kayan sinadarai na magunguna, ana iya amfani da shikimic acid don maganin cututtuka da yawa:

1. Antibacterial da antitumor

A cikin 1987, malaman Jafananci sun gano cewa analog na glioxalase I inhibitor wanda aka haɗa ta methyl anthranilate yana da tasirin hanawa a kan layin salula na Hela da Escheri ascites carcinoma, na iya tsawaita lokacin rayuwa na berayen da aka yi wa ƙwayar cutar sankarar bargo L1210, kuma yawan guba yana da ƙasa kaɗan. tasirin hanawa yana da alaƙa da halayen sulfur hydride. 1988, malaman kasar Sin sun yi A cikin 1988, malaman kasar Sin sun hada wani nau'i na shikimic acid kuma sun tabbatar da cewa wannan fili yana da tasirin hana cutar sankarar bargo L1210 a cikin vitro.

2. Anti-thrombosis

Ana nuna tasirin shikimic acid da abubuwan da ke tattare da shi akan tsarin jijiyoyin jini a cikin rawar anti-thrombosis da hana haɓakar platelet. Bincike ya nuna cewa: shikimic acid yana da tasiri mai ƙarfi na hanawa a kan adadin tarawar platelet na adenosine diphosphate-induced tsakiyar cerebral artery embolism model berayen; allurar shikimic acid ta cikin jini da ta mussuka na iya sanya lokacin daskarewar jini na mice ya tsawaita.

3.Anti-cerebral ischemia

Shikimic acid da abubuwan da suka samo asali suna da tasirin inganta haɓakar ischemia na cerebral, galibi a cikin rage ƙarar ƙwayar ƙwayar cuta bayan mai da hankali kan ischemia a cikin berayen, rage ma'aunin aikin jijiya, rage ma'aunin edema na cerebral, ƙara yawan kwararar jini a cikin yankin ischemic. da sauran alamomi. Wasu nazarin sun nuna cewa abubuwan da suka samo asali na iya rage yawan ƙwayar erythrocyte da kuma hana haɗuwar platelet bayan ischemia na cerebral, don haka sauƙaƙe microcirculation na kwakwalwa.