A cikin wani sabon bincike, masu bincike sun gano cewa sabon magani da aka yi amfani da shi wajen cire 'ya'yan inabi zai iya tsawaita tsawon rai da lafiyar beraye cikin nasara.
Binciken, wanda aka buga a mujallar Nature Metabolism, ya shimfida harsashin ƙarin nazarin asibiti don tantance ko za a iya kwaikwayon waɗannan tasirin a cikin mutane.
Tsufa babbar matsala ce ga cututtuka masu tsanani da yawa. Masana kimiyya sun yi imanin cewa wannan wani ɓangare ne na tsufar ƙwayoyin halitta. Wannan yana faruwa ne lokacin da ƙwayoyin halitta ba za su iya yin ayyukansu na halitta a jiki ba.
A cikin 'yan shekarun nan, masu bincike sun gano wani nau'in magunguna da ake kira senolytics. Waɗannan magunguna na iya lalata ƙwayoyin tsufa a cikin gwaje-gwaje da samfuran dabbobi, wanda hakan na iya rage yawan kamuwa da cututtuka masu tsanani da ke tasowa yayin da muke tsufa kuma muke rayuwa tsawon lokaci.
A cikin wannan binciken, masana kimiyya sun gano wani sabon sinadarin senolytic da aka samo daga wani sinadari na cirewar 'ya'yan inabi mai suna proanthocyanidin C1 (PCC1).
Dangane da bayanan da suka gabata, ana sa ran PCC1 zai hana aikin ƙwayoyin tsufa a ƙananan yawan ƙwayoyin halitta kuma zai iya lalata ƙwayoyin tsufa a mafi yawan ƙwayoyin halitta.
A gwajin farko, sun fallasa beraye ga allurar radiation marasa mutuwa don haifar da tsufa a cikin ƙwayoyin halitta. Ɗaya daga cikin beraye ya sami PCC1, ɗayan kuma ya sami abin hawa ɗauke da PCC1.
Masu binciken sun gano cewa bayan da aka fallasa beraye ga hasken rana, sun sami halaye na zahiri marasa kyau, ciki har da yawan furfura.
Maganin beraye da PCC1 ya canza waɗannan halaye sosai. Berayen da aka ba PCC1 suma suna da ƙarancin ƙwayoyin tsufa da alamun bayyanar cututtuka da ke da alaƙa da ƙwayoyin tsufa.
A ƙarshe, beraye da aka yi wa haske ba su da ƙarfin aiki da ƙarfin tsoka. Duk da haka, yanayin ya canza a cikin beraye idan aka yi la'akari da PCC1, kuma suna da ƙimar rayuwa mafi girma.
A gwaji na biyu, masu binciken sun yi wa beraye masu tsufa allurar PCC1 ko abin hawa duk bayan mako biyu na tsawon watanni hudu.
Tawagar ta gano adadi mai yawa na ƙwayoyin halitta masu tsufa a cikin kodan, hanta, huhu da kuma prostate na tsoffin beraye. Duk da haka, maganin da aka yi da PCC1 ya canza yanayin.
Berayen da aka yi wa magani da PCC1 sun kuma nuna ci gaba a ƙarfin riƙewa, saurin tafiya mai yawa, juriyar ratayewa, juriyar na'urar motsa jiki, matakin ayyukan yau da kullun, da daidaito idan aka kwatanta da beraye waɗanda suka sami abin hawa su kaɗai.
A wani gwaji na uku, masu binciken sun duba tsofaffin beraye don ganin yadda PCC1 ke shafar rayuwarsu.
Sun gano cewa beraye da aka yi wa magani da PCC1 sun rayu matsakaicin kashi 9.4% fiye da beraye da aka yi wa magani da abin hawa.
Bugu da ƙari, duk da tsawon rai, beraye da aka yi wa magani da PCC1 ba su nuna wata babbar matsala da ta shafi shekaru ba idan aka kwatanta da beraye da aka yi wa magani da mota.
A taƙaice binciken, marubuciyar da ta yi magana da Farfesa Sun Yu daga Cibiyar Abinci da Lafiya ta Shanghai da ke China da abokan aikinsa sun ce: "Muna bayar da shaidar ƙa'ida cewa [PCC1] yana da ikon jinkirta matsalar da ta shafi tsufa ko da lokacin da aka sha shi." Daga baya a rayuwa, yana da babban damar rage cututtukan da suka shafi tsufa da kuma inganta sakamakon lafiya, ta haka ne zai buɗe sabbin hanyoyi don maganin tsofaffi na gaba don inganta lafiya da tsawon rai."
Dakta James Brown, memba na Cibiyar Aston Center for Healthy Aging da ke Birmingham, Birtaniya, ya shaida wa Jaridar Medical News Today cewa binciken ya ba da ƙarin shaida game da fa'idodin magungunan hana tsufa. Dr. Brown bai shiga cikin binciken da aka yi kwanan nan ba.
"Senolytics wani sabon nau'in sinadarai ne na hana tsufa wanda aka fi samu a yanayi. Wannan binciken ya nuna cewa PCC1, tare da sinadarai kamar quercetin da fisetin, suna iya kashe ƙwayoyin halitta masu tsufa da kansu yayin da suke barin ƙananan ƙwayoyin halitta masu lafiya su ci gaba da rayuwa mai kyau."
"Wannan binciken, kamar sauran bincike a wannan fanni, ya binciki tasirin waɗannan sinadarai a cikin beraye da sauran ƙananan halittu, har yanzu akwai aiki mai yawa kafin a iya tantance tasirin waɗannan sinadarai a jikin ɗan adam."
"Hakika magungunan Senolytics suna da alƙawarin zama manyan magungunan hana tsufa a ci gaba," in ji Dr. Brown.
Farfesa Ilaria Bellantuono, farfesa a fannin tsufa a tsoka da ƙashi a Jami'ar Sheffield da ke Burtaniya, ta amince a wata hira da MNT cewa babbar tambayar ita ce ko za a iya kwaikwayi waɗannan binciken a cikin mutane. Farfesa Bellantuono shi ma bai shiga cikin binciken ba.
"Wannan binciken ya ƙara shaida cewa amfani da magungunan da ke kashe ƙwayoyin halitta masu tsufa, waɗanda ake kira 'senolytics', na iya inganta aikin jiki yayin da muke tsufa kuma suna sa magungunan chemotherapy su fi tasiri a kan cutar kansa."
"Yana da mahimmanci a lura cewa duk bayanan da ke cikin wannan fanni sun fito ne daga samfuran dabbobi - a wannan yanayin, samfuran beraye. Babban ƙalubalen shine a gwada ko waɗannan magungunan suna da tasiri iri ɗaya [a cikin mutane]. Babu bayanai da ake da su a yanzu." , kuma gwaje-gwajen asibiti sun fara ne kawai," in ji Farfesa Bellantuono.
Dakta David Clancy, daga Faculty of Biomedicine and Biological Sciences a Jami'ar Lancaster da ke Burtaniya, ya shaida wa MNT cewa matakan allurar na iya zama matsala yayin amfani da sakamakon ga mutane. Dr. Clancy ba ta da hannu a cikin binciken da aka yi kwanan nan.
"Allunan da ake bai wa beraye galibi suna da yawa idan aka kwatanta da abin da mutane za su iya jurewa. Dogayen allurai na PCC1 a jikin mutane na iya haifar da guba. Nazarin da ake yi a kan beraye na iya zama abin fahimta; hantarsu tana kama da tana sarrafa magunguna kamar hanta ta ɗan adam fiye da hanta ta beraye."
Dakta Richard Siow, darektan binciken tsufa a Kwalejin King's London, shi ma ya shaida wa MNT cewa binciken dabbobi ba na ɗan adam ba ba lallai bane ya haifar da sakamako mai kyau a asibiti ga mutane. Dakta Siow shi ma bai shiga cikin binciken ba.
"Ba koyaushe nake kwatanta gano beraye, tsutsotsi da kwari da mutane ba, domin abu ɗaya tilo shine muna da asusun banki amma ba su da su. Muna da walat, amma ba su da su. Muna da wasu abubuwa a rayuwa. A jaddada cewa dabbobi ba mu da su: abinci, sadarwa, aiki, kiran Zoom. Na tabbata ana iya damuwa da beraye ta hanyoyi daban-daban, amma yawanci muna damuwa da ma'aunin bankinmu," in ji Dr. Xiao.
"Tabbas, wannan abin dariya ne, amma idan aka yi la'akari da mahallin, duk abin da ka karanta game da beraye ba za a iya fassara shi zuwa ga mutane ba. Idan kai beraye ne kuma kana son rayuwa har ka kai shekara 200 - ko kuma daidai da beraye. Idan kana da shekara 200, hakan zai yi kyau, amma shin yana da ma'ana ga mutane? Wannan koyaushe abin gargaɗi ne idan ina magana game da binciken dabbobi."
"A gefe mai kyau, wannan bincike ne mai ƙarfi wanda ke ba mu shaida mai ƙarfi cewa ko da yawancin hanyoyin da bincikena ya mayar da hankali a kansu suna da mahimmanci idan muka yi tunanin rayuwa gabaɗaya."
"Ko dai samfurin dabba ne ko samfurin ɗan adam, akwai wasu takamaiman hanyoyin ƙwayoyin halitta da muke buƙatar duba a cikin mahallin gwaje-gwajen asibiti na ɗan adam tare da mahadi kamar proanthocyanidins na tsaban innabi," in ji Dr. Siow.
Dr. Xiao ya ce akwai yiwuwar a samar da sinadarin 'ya'yan inabi a matsayin wani ƙarin abinci.
"Samun kyakkyawan samfurin dabbobi tare da sakamako mai kyau [da kuma bugawa a cikin mujallar da ke da tasiri sosai] yana ƙara nauyi ga ci gaba da saka hannun jari a cikin binciken asibiti na ɗan adam, ko daga gwamnati, gwaje-gwajen asibiti ko ta hanyar masu zuba jari da masana'antu. Karɓi wannan kwamitin ƙalubalen kuma a saka 'ya'yan inabi a cikin allunan a matsayin ƙarin abinci bisa ga waɗannan labaran."
"Ba a gwada ƙarin abincin da nake sha a asibiti ba, amma bayanan dabbobi sun nuna cewa yana ƙara nauyi - wanda hakan ke sa masu amfani su yi imani da cewa akwai wani abu a ciki. Yana daga cikin yadda mutane ke tunani game da abinci." Ta wasu hanyoyi, wannan yana da amfani don fahimtar tsawon rai, in ji Dr. Xiao.
Dr. Xiao ya jaddada cewa ingancin rayuwar mutum ma yana da mahimmanci, ba wai tsawon lokacin da yake rayuwa ba.
"Idan muna damuwa da tsawon rai, kuma mafi mahimmanci, tsawon rai, muna buƙatar fayyace ma'anar tsawon rai. Babu matsala idan muka rayu har muka kai shekaru 150, amma ba zai yi kyau ba idan muka shafe shekaru 50 da suka gabata a kan gado."
"Don haka maimakon tsawon rai, wataƙila lokaci mafi kyau shine lafiya da tsawon rai: wataƙila kana ƙara shekaru a rayuwarka, amma kana ƙara shekaru a rayuwarka? Ko kuwa waɗannan shekarun ba su da ma'ana? Kuma lafiyar kwakwalwa: za ka iya rayuwa har zuwa shekaru 130. Amma idan ba za ka iya jin daɗin waɗannan shekarun ba, shin ya cancanci hakan?"
"Yana da mahimmanci mu duba faffadan hangen nesa na lafiyar kwakwalwa da walwala, rauni, matsalolin motsi, da kuma yadda muke tsufa a cikin al'umma - shin akwai isassun magunguna? Ko kuma muna buƙatar ƙarin kulawa ta zamantakewa? Idan muna da tallafi don rayuwa har zuwa shekaru 90, 100 ko 110? Shin gwamnati tana da wata manufa?"
"Idan waɗannan magunguna suna taimaka mana, kuma mun wuce shekaru 100, me za mu iya yi don inganta rayuwarmu maimakon kawai shan ƙarin ƙwayoyi? Ga tsaban innabi, rumman, da sauransu," in ji Dr. Xiao. .
Farfesa Bellantuono ya ce sakamakon binciken zai yi matuƙar amfani ga gwaje-gwajen asibiti da suka shafi marasa lafiya da ke fama da cutar kansa waɗanda ke karɓar maganin chemotherapy.
"Wani ƙalubale da aka saba fuskanta game da maganin senolytics shine tantance wanda zai amfana da su da kuma yadda za a auna fa'ida a gwaje-gwajen asibiti."
"Bugu da ƙari, saboda magunguna da yawa sun fi tasiri wajen hana cututtuka maimakon magance su da zarar an gano su, gwaje-gwajen asibiti na iya ɗaukar shekaru dangane da yanayin kuma za su yi tsada sosai."
"Duk da haka, a wannan yanayin, [masu binciken] sun gano ƙungiyar marasa lafiya da za su amfana da shi: marasa lafiya da ke fama da cutar kansa da ke karɓar maganin chemotherapy. Bugu da ƙari, an san lokacin da ake haifar da samuwar ƙwayoyin tsufa (watau ta hanyar chemotherapy) da kuma lokacin da "Wannan kyakkyawan misali ne na binciken hujjar ra'ayi wanda za a iya yi don gwada ingancin maganin senolytics a cikin marasa lafiya," in ji Farfesa Bellantuono.
Masana kimiyya sun yi nasarar kawar da alamun tsufa a cikin beraye ta hanyar sake tsara wasu ƙwayoyin halittarsu ta hanyar kwayoyin halitta.
Wani bincike da Kwalejin Kimiyya ta Baylor ta gudanar ya gano cewa kari yana rage ko gyara wasu sassan tsufa na halitta a cikin beraye, wanda hakan ke iya tsawaita…
Wani sabon bincike da aka gudanar a kan beraye da ƙwayoyin halittar ɗan adam ya gano cewa sinadaran 'ya'yan itace na iya rage hawan jini. Binciken ya kuma bayyana hanyar da za a bi don cimma wannan buri.
Masana kimiyyar sun zuba jinin tsofaffin beraye a cikin ƙananan beraye domin su lura da tasirin da kuma yadda suka rage tasirinsa.
Abincin hana tsufa yana ƙara shahara. A cikin wannan labarin, za mu tattauna sakamakon binciken da aka yi kwanan nan kan shaidun kuma mu tambayi ko akwai wani daga cikin…