A wani sabon bincike da aka gudanar, masu bincike sun gano cewa wani sabon magani da aka yi amfani da shi a wani bangaren da ake fitar da 'ya'yan inabi zai iya samun nasarar tsawaita tsawon rayuwa da lafiyar beraye.
Binciken, wanda aka buga a cikin mujallar Nature Metabolism, ya kafa harsashi don ƙarin nazarin asibiti don sanin ko za a iya yin irin wannan tasirin a cikin mutane.
Tsufa shine babban abin haɗari ga yawancin cututtuka na yau da kullun.Masana kimiyya sun yi imanin wannan wani bangare ne saboda tsufa na salula.Wannan yana faruwa ne lokacin da kwayoyin halitta ba za su iya yin ayyukansu na halitta ba a cikin jiki.
A cikin 'yan shekarun nan, masu bincike sun gano wani nau'in magungunan da ake kira senolytics.Waɗannan magungunan na iya lalata ƙwayoyin ji a cikin dakin gwaje-gwaje da nau'ikan dabbobi, mai yuwuwar rage haɗarin cututtukan da ke tasowa yayin da muke tsufa da rayuwa.
A cikin wannan binciken, masana kimiyya sun gano wani sabon senolytic da aka samu daga wani bangaren tsantsar irin inabi mai suna proanthocyanidin C1 (PCC1).
Dangane da bayanan da suka gabata, ana sa ran PCC1 zai hana ayyukan sel masu hankali a ƙananan ƙima da zaɓin lalata ƙwayoyin ji a mafi girma.
A cikin gwaji na farko, sun fallasa beraye zuwa ƙananan allurai na radiation don haifar da jin daɗin salula.Sai rukuni ɗaya na berayen sun karɓi PCC1, ɗayan kuma sun karɓi motar ɗauke da PCC1.
Masu binciken sun gano cewa bayan da berayen suka gamu da hasashe, sun samu wasu halaye marasa kyau na jiki, wadanda suka hada da gashin toka mai yawa.
Maganin beraye tare da PCC1 ya canza waɗannan halayen sosai.Berayen da aka ba PCC1 suma suna da ƙarancin sel masu tsini da alamomin halittu masu alaƙa da ƙwayoyin ji.
A ƙarshe, berayen da aka lalata sun sami ƙarancin aiki da ƙarfin tsoka.Koyaya, yanayin ya canza a cikin berayen da aka ba PCC1, kuma suna da ƙimar rayuwa mafi girma.
A gwaji na biyu, masu binciken sun yi allurar tsofaffin beraye da PCC1 ko abin hawa kowane mako biyu na tsawon watanni hudu.
Tawagar ta gano adadi mai yawa na kwayoyin halitta a cikin koda, hanta, huhu da prostate na tsofaffin beraye.Koyaya, jiyya tare da PCC1 ya canza yanayin.
Berayen da aka yi musu magani tare da PCC1 sun kuma nuna haɓakar ƙarfin riko, matsakaicin saurin tafiya, juriyar rataye, juriyar juriya, matakin ayyukan yau da kullun, da daidaito idan aka kwatanta da mice waɗanda suka karɓi abin hawa kaɗai.
A gwaji na uku, masu binciken sun kalli tsofaffin beraye don ganin yadda PCC1 ya shafi tsawon rayuwarsu.
Sun gano cewa berayen da aka yi musu magani da PCC1 sun rayu matsakaicin kashi 9.4% fiye da berayen da aka yi musu magani da abin hawa.
Bugu da ƙari, duk da tsawon rayuwa, berayen da aka yi wa PCC1 ba su nuna wata cuta mai girma da ta shafi shekaru ba idan aka kwatanta da berayen da abin hawa ke yi.
Da yake taƙaita sakamakon binciken, marubucin nan Farfesa Sun Yu daga Cibiyar Kula da Abinci da Lafiya ta Shanghai da ke China da abokan aikinmu sun ce: "A nan muna ba da tabbacin ƙa'ida cewa [PCC1] na da ikon jinkirta tabarbarewar shekaru ko da an sha."daga baya a rayuwa, yana da babban damar rage cututtukan da ke da alaƙa da shekaru da haɓaka sakamakon kiwon lafiya, ta yadda za a buɗe sabbin hanyoyin da za a iya amfani da magungunan geriatric nan gaba don inganta lafiya da tsawon rai.”
Dokta James Brown, memba na Cibiyar Aston don Tsofaffi da Lafiyar Jama'a a Birmingham, Burtaniya, ya shaidawa Medical News A Yau cewa binciken ya ba da ƙarin shaida na yuwuwar fa'idodin magungunan rigakafin tsufa.Dr. Brown bai shiga cikin binciken na baya-bayan nan ba.
"Senolytics wani sabon nau'i ne na mahadi masu tsufa waɗanda aka saba samu a yanayi.Wannan binciken ya nuna cewa PCC1, tare da mahadi irin su quercetin da fisetin, suna iya zaɓin kashe kwayoyin halitta yayin da suke ƙyale matasa, sel masu lafiya su kula da ingantaccen aiki.”
"Wannan binciken, kamar sauran binciken da aka yi a wannan yanki, ya yi nazari akan tasirin waɗannan mahadi a cikin rodents da sauran ƙananan kwayoyin halitta, aiki da yawa ya rage kafin a iya ƙayyade tasirin maganin tsufa na waɗannan mahadi a cikin mutane."
"Lalle ne Senolytics yana riƙe da alƙawarin kasancewa manyan magungunan rigakafin tsufa a cikin ci gaba," in ji Dokta Brown.
Farfesa Ilaria Bellantuono, farfesa a fannin tsufa na tsoka a Jami'ar Sheffield da ke Burtaniya, ya yarda a wata hira da MNT cewa babbar tambaya ita ce ko za a iya maimaita waɗannan binciken a cikin mutane.Farfesa Bellantuono shi ma bai shiga cikin binciken ba.
"Wannan binciken yana ƙarawa a jikin shaidun da ke nuna cewa yin niyya ga kwayoyin halitta da magungunan da ke kashe su, wanda ake kira 'senolytics,' na iya inganta aikin jiki yayin da muke tsufa da kuma sa magungunan chemotherapy mafi tasiri a cikin ciwon daji."
"Yana da mahimmanci a lura cewa duk bayanan da ke cikin wannan yanki sun fito ne daga nau'ikan dabbobi - a wannan yanayin, ƙirar linzamin kwamfuta.Babban kalubalen shine a gwada ko waɗannan magungunan suna da tasiri daidai da [a cikin mutane].Babu bayanai da ake samu a wannan lokacin.", kuma gwaji na asibiti ya fara farawa,” in ji Farfesa Bellantuono.
Dokta David Clancy, daga Kwalejin Biomedicine da Kimiyyar Halittu a Jami'ar Lancaster da ke Burtaniya, ya gaya wa MNT cewa matakan kashi na iya zama matsala yayin amfani da sakamakon ga mutane.Dr. Clancy bai shiga cikin binciken kwanan nan ba.
“Magungunan da ake ba wa beraye galibi suna da yawa sosai idan aka kwatanta da abin da mutane za su iya jurewa.Abubuwan da suka dace na PCC1 a cikin mutane na iya haifar da guba.Nazarin a cikin berayen na iya zama mai ba da labari;hantar su ta bayyana tana daidaita magunguna kamar hantar mutum fiye da hantar linzamin kwamfuta.”
Dokta Richard Siow, darektan binciken tsufa a Kwalejin King London, ya kuma shaida wa MNT cewa binciken da ba na dabba ba na iya haifar da sakamako mai kyau na asibiti a cikin mutane.Dr. Siow kuma bai shiga cikin binciken ba.
“Ba koyaushe nake kwatanta gano beraye da tsutsotsi da kwari da mutane ba, domin abu mai sauki shi ne muna da asusun banki amma ba su da.Muna da wallet, amma ba su da.Muna da sauran abubuwa a rayuwa.Jaddada cewa dabbobi Ba mu da: abinci, sadarwa, aiki, Zuƙowa kira.Na tabbata ana iya damuwa da beraye ta hanyoyi daban-daban, amma yawanci mun fi damuwa da ma’auni na bankinmu,” in ji Dokta Xiao.
"Hakika, wannan wasa ne, amma ga mahallin, duk abin da kuka karanta game da beraye ba za a iya fassara shi zuwa ga mutane ba.Idan kun kasance linzamin kwamfuta kuma kuna son rayuwa har zuwa shekaru 200 - ko kuma kwatankwacin linzamin kwamfuta.A shekaru 200, wannan zai yi kyau, amma yana da ma'ana ga mutane?Wannan ko da yaushe abin ban mamaki ne idan na yi magana game da binciken dabbobi.”
"A gefe mai kyau, wannan bincike ne mai ƙarfi wanda ke ba mu shaida mai ƙarfi cewa ko da yawancin hanyoyin da na fi mayar da hankali kan bincike na da mahimmanci lokacin da muke tunanin tsawon rayuwa gabaɗaya."
"Ko samfurin dabba ne ko samfurin mutum, za a iya samun wasu hanyoyi na musamman na kwayoyin halitta da muke buƙatar duba a cikin mahallin gwajin asibiti na mutum tare da mahadi kamar nau'in innabi proanthocyanidins," in ji Dokta Siow.
Dokta Xiao ya ce wata yuwuwar ita ce samar da tsantsar irin innabi a matsayin abin da ake ci.
"Samun samfurin dabba mai kyau tare da sakamako mai kyau [da kuma bugawa a cikin jarida mai mahimmanci] yana ƙara nauyi ga ci gaba da zuba jarurruka a cikin bincike na asibiti na mutum, ko daga gwamnati, gwaji na asibiti ko ta hanyar masu zuba jari da masana'antu.Ɗauki wannan kwamiti na ƙalubale kuma sanya tsaba na inabi a cikin allunan a matsayin kari na abinci bisa waɗannan labaran. "
“Karin da nake sha mai yiwuwa ba a gwada shi a asibiti ba, amma bayanan dabbobi sun nuna yana ƙara nauyi - wanda ke sa masu amfani su yarda cewa akwai wani abu a ciki.Yana daga cikin yadda mutane suke tunanin abinci.”Additives."a wasu hanyoyi, wannan yana da amfani wajen fahimtar tsawon rai,” in ji Dokta Xiao.
Dokta Xiao ya jaddada cewa, yanayin rayuwar mutum yana da muhimmanci, ba kawai tsawon rayuwarsa ba.
"Idan muka damu da tsawon rayuwa kuma, mafi mahimmanci, tsawon rayuwa, muna buƙatar ayyana ma'anar tsawon rai.Yana da kyau idan muna rayuwa har zuwa 150, amma ba kyau sosai idan muka shafe shekaru 50 na ƙarshe a gado. "
"Don haka maimakon tsawon rai, watakila mafi kyawun lokaci zai zama lafiya da tsawon rai: da kyau za ku ƙara shekaru a rayuwar ku, amma kuna ƙara shekaru a rayuwar ku?Ko shekarun nan ba su da ma'ana?Kuma lafiyar hankali: za ku iya rayuwa har zuwa shekaru 130.tsofaffi, amma idan ba za ku iya jin daɗin waɗannan shekarun ba, yana da daraja?"
"Yana da mahimmanci mu dubi faffadan hangen nesa game da lafiyar kwakwalwa da walwala, rauni, matsalolin motsi, yadda muke tsufa a cikin al'umma - shin akwai isassun magunguna?Ko muna buƙatar ƙarin kulawar zamantakewa?Idan muna da tallafi don rayuwa zuwa 90, 100 ko 110?Shin gwamnati na da manufa?"
“Idan waɗannan magungunan suna taimaka mana, kuma mun haura shekaru 100, menene za mu yi don inganta rayuwarmu maimakon shan ƙarin ƙwayoyi?Anan kuna da tsaban inabi, rumman, da sauransu,” in ji Dokta Xiao..
Farfesa Bellantuono ya ce sakamakon binciken zai kasance mai mahimmanci musamman ga gwaje-gwajen asibiti da suka shafi masu cutar kansa da ke karbar maganin chemotherapy.
"Kalubalen gama gari tare da senolytics shine tantance wanda zai amfana da su da kuma yadda za'a auna fa'ida a cikin gwaje-gwajen asibiti."
"Bugu da ƙari, saboda magunguna da yawa sun fi tasiri wajen hana cututtuka maimakon magance ta da zarar an gano ta, gwajin asibiti na iya ɗaukar shekaru dangane da yanayin kuma zai yi tsada sosai."
"Duk da haka, a cikin wannan yanayin musamman, [masu binciken] sun gano ƙungiyar marasa lafiya da za su amfana da shi: masu ciwon daji suna karɓar chemotherapy.Bugu da ƙari, an san lokacin da aka haifar da samuwar kwayoyin halitta (watau ta hanyar chemotherapy) da kuma lokacin da "Wannan misali ne mai kyau na bincike-binciken ra'ayi wanda za a iya yi don gwada tasirin senolytics a cikin marasa lafiya," in ji Farfesa. Bellantuono.”
Masana kimiyya sun yi nasara kuma cikin aminci sun juyar da alamun tsufa a cikin beraye ta hanyar sake tsara wasu kwayoyin halittarsu.
Wani binciken Kwalejin Kimiyya na Baylor ya gano cewa kari yana rage jinkiri ko gyara yanayin tsufa a cikin beraye, mai yuwuwar tsawaita…
Wani sabon bincike a cikin mice da sel ɗan adam ya gano cewa mahadi na 'ya'yan itace na iya rage hawan jini.Har ila yau binciken ya bayyana hanyoyin cimma wannan buri.
Masanan sun cusa jinin tsofaffin beraye a cikin kananan beraye don lura da illar da kuma ganin ko da kuma yadda suka rage tasirinsa.
Abincin rigakafin tsufa yana ƙara shahara.A cikin wannan labarin mun tattauna sakamakon binciken da aka yi na kwanan nan game da shaidar kuma mu tambayi ko wani…