Daga cikin sabbin takardu kan wannan maganin antioxidant mai ƙarfi akwai wani bita da aka buga a cikin Binciken Phytotherapy a watan Maris na 2019, wanda ya yi bitar abubuwa 9 game da tasirin quercetin akan cututtukan metabolism Gwajin sarrafawa mara tsari.

Ciwon metabolism yana nufin jerin matsalolin lafiya waɗanda ke ƙara haɗarin kamuwa da ciwon suga na nau'in 2, cututtukan zuciya, da bugun jini, gami da hawan jini, yawan sukari a jini, yawan triglycerides, da tarin kitse a kugu.

Duk da cewa bincike mai zurfi ya gano cewa quercetin ba shi da wani tasiri ga azumin glucose, juriya ga insulin ko matakan hemoglobin A1c, ƙarin bincike na rukuni ya nuna cewa an ƙara quercetin a cikin binciken da aka ɗauki aƙalla 500 MG kowace rana na tsawon akalla makonni takwas.

Quercetin yana taimakawa wajen daidaita bayyanar kwayoyin halitta

A cewar wani bincike da aka buga a shekarar 2016, quercetin na iya kunna tashar mitochondrial na apoptosis (mutuwar ƙwayoyin da aka tsara don lalacewa) ta hanyar hulɗa da DNA, wanda hakan ke haifar da koma baya ga ciwace-ciwacen daji.

Bincike ya gano cewa quercetin na iya haifar da guba ga ƙwayoyin cutar sankarar bargo, kuma tasirin yana da alaƙa da yawan shan maganin. An kuma gano ƙarancin tasirin guba ga ƙwayoyin cutar kansar nono. Gabaɗaya, quercetin na iya tsawaita rayuwar beraye masu fama da cutar kansa sau 5 idan aka kwatanta da ƙungiyar da ba a ba su magani ba.

Marubutan sun danganta waɗannan tasirin ga hulɗar kai tsaye tsakanin quercetin da DNA da kuma kunna hanyar mitochondrial ta apoptosis, kuma sun ba da shawarar cewa yuwuwar amfani da quercetin a matsayin maganin taimako don maganin ciwon daji ya cancanci ƙarin bincike.

Wani bincike da aka buga kwanan nan a cikin mujallar Molecules ya kuma jaddada tasirin epigenetic na quercetin da ikonsa na:

Hulɗa da tashoshin siginar tantanin halitta
Daidaita bayyanar kwayoyin halitta
Shafi ayyukan abubuwan da ke ɗauke da bayanai
Yana daidaita microribonucleic acid (microRNA)

An taɓa ɗaukar microribonucleic acid a matsayin "jakar DNA". Bincike ya gano cewa "jakar DNA" ba ta da amfani ko kaɗan. A zahiri ƙaramin ƙwayar ribonucleic acid ce, wadda ke taka muhimmiyar rawa wajen daidaita kwayoyin halittar da ke samar da sunadaran ɗan adam.

Ana iya amfani da sinadarin microribonucleic acid a matsayin "canzawa" na waɗannan kwayoyin halitta. Dangane da shigar da sinadarin microribonucleic acid, kwayar halitta na iya ƙunsar kowace daga cikin samfuran furotin sama da 200. Ikon Quercetin na daidaita microRNAs na iya kuma bayyana tasirin sa na cytotoxic da kuma dalilin da ya sa yake ƙara rayuwar ciwon daji (aƙalla ga beraye).

Quercetin wani sinadari ne mai ƙarfi na maganin kashe ƙwayoyin cuta

Kamar yadda aka ambata a sama, binciken da aka gudanar game da quercetin ya mayar da hankali kan ikonsa na kashe ƙwayoyin cuta, wanda galibi ya faru ne saboda hanyoyi uku na aiki:

Hana ikon ƙwayoyin cuta na kamuwa da ƙwayoyin halitta
Hana kwafi na ƙwayoyin da suka kamu da cutar
Rage juriyar ƙwayoyin da suka kamu da cutar ga maganin magungunan kashe ƙwayoyin cuta

Misali, wani bincike da Ma'aikatar Tsaro ta Amurka ta dauki nauyin gudanarwa wanda aka buga a shekarar 2007 ya gano cewa bayan fuskantar matsanancin damuwa na jiki, quercetin na iya rage barazanar kamuwa da kwayar cutar da kuma inganta aikin kwakwalwarka, in ba haka ba yana iya lalata aikin garkuwar jikinka, wanda hakan ke sa ka fi kamuwa da cututtuka.

A cikin wannan binciken, masu keke sun sami 1000 mg na quercetin a rana, tare da bitamin C (ƙara yawan quercetin a cikin plasma) da niacin (yana haɓaka shan ruwa) na tsawon makonni biyar a jere. Sakamakon ya gano cewa idan aka kwatanta da waɗanda ba a ba su magani ba. Ga duk wanda aka yi wa magani, waɗanda suka sha quercetin suna da ƙarancin damar kamuwa da cutar kwayar cuta bayan sun hau keke na tsawon awanni uku a rana na tsawon kwanaki uku a jere. Kashi 45% na mutanen da ke cikin rukunin placebo suna rashin lafiya, yayin da kashi 5% kawai na mutanen da ke cikin rukunin jiyya ke rashin lafiya.

Hukumar Ayyukan Bincike na Ci Gaba ta Tsaro ta Amurka (DARPA) ta dauki nauyin wani bincike, wanda aka buga a shekarar 2008, kuma ta yi nazarin amfani da kwayar cutar mura ta H1N1 mai saurin yaduwa don kalubalantar dabbobin da aka yi wa magani da quercetin. Sakamakon har yanzu iri daya ne, rashin lafiya da mace-macen rukunin jiyya sun yi kasa sosai da na rukunin placebo. Wasu nazarce-nazarce sun kuma tabbatar da ingancin quercetin akan nau'ikan ƙwayoyin cuta iri-iri, ciki har da:

Wani bincike da aka gudanar a shekarar 1985 ya gano cewa quercetin na iya hana kamuwa da cuta da kuma kwafi na kwayar cutar herpes simplex nau'in 1, kwayar cutar poliovirus nau'in 1, kwayar cutar parainfluenza nau'in 3, da kuma kwayar cutar syncytial ta numfashi.

Wani bincike da aka gudanar a kan dabbobi a shekarar 2010 ya gano cewa quercetin na iya hana ƙwayoyin cuta na mura A da B. Akwai kuma manyan bincike guda biyu. Na farko, waɗannan ƙwayoyin cuta ba za su iya haifar da juriya ga quercetin ba; na biyu, idan aka yi amfani da su tare da magungunan kashe ƙwayoyin cuta (amantadine ko oseltamivir), tasirinsu yana ƙaruwa sosai - kuma ana hana ci gaban juriya.

Wani bincike da aka gudanar a kan dabbobi a shekarar 2004 ya amince da wani nau'in kwayar cutar H3N2, inda ya binciki tasirin quercetin akan mura. Marubucin ya nuna cewa:

"A lokacin kamuwa da kwayar cutar mura, damuwa ta oxidative na faruwa. Saboda quercetin na iya dawo da yawan antioxidants da yawa, wasu mutane suna tunanin yana iya zama magani mai tasiri wanda zai iya kare huhu daga sakin su yayin kamuwa da kwayar cutar mura. Illolin da ke tattare da radicals marasa iskar oxygen."

Wani bincike da aka gudanar a shekarar 2016 ya gano cewa quercetin na iya daidaita bayyanar furotin kuma yana da tasirin kariya ga kwayar cutar mura ta H1N1. Musamman ma, daidaita furotin mai girgiza zafi, fibronectin 1 da furotin mai hanawa suna taimakawa wajen rage kwafi na kwayar cutar.

Wani bincike na uku da aka buga a shekarar 2016 ya gano cewa quercetin na iya hana nau'ikan nau'ikan mura iri-iri, ciki har da H1N1, H3N2, da H5N1. Marubucin rahoton binciken ya yi imanin cewa, "Wannan binciken ya nuna cewa quercetin yana nuna aikin hana kamuwa da mura a farkon matakin kamuwa da mura, wanda ke samar da tsarin magani mai yuwuwa a nan gaba ta hanyar haɓaka magunguna masu inganci, aminci, kuma masu araha don magancewa da hana kamuwa da cutar [Influenza A virus].

A shekarar 2014, masu bincike sun nuna cewa quercetin "yana da alama yana da kyau a cikin maganin mura da ƙwayoyin cuta na rhinovirus ke haifarwa" kuma sun ƙara da cewa, "Bincike ya tabbatar da cewa quercetin na iya rage shigar ƙwayoyin cuta cikin jiki da kuma kwafi a cikin jiki. Jiki na iya rage yawan ƙwayoyin cuta, ciwon huhu da kuma yawan amsawar iska."

Quercetin kuma yana iya rage lalacewar iskar oxygen, ta haka yana rage haɗarin kamuwa da cututtukan ƙwayoyin cuta na biyu, waɗanda sune babban dalilin mutuwar da suka shafi mura. Abu mafi mahimmanci, quercetin yana ƙara yawan ƙwayoyin halittar mitochondrial a cikin tsokoki na ƙashi, yana nuna cewa wani ɓangare na tasirinsa na rigakafi yana faruwa ne saboda haɓakar siginar rigakafi ta mitochondrial.

Wani bincike da aka gudanar a dabbobi a shekarar 2016 ya gano cewa quercetin na iya hana kwayar cutar dengue da kuma kamuwa da kwayar cutar hepatitis a cikin beraye. Wasu bincike sun kuma tabbatar da cewa quercetin yana da ikon hana kamuwa da cutar hepatitis B da C.

Kwanan nan, wani bincike da aka buga a mujallar Microbial Pathogenesis a watan Maris na 2020 ya gano cewa quercetin na iya samar da cikakken kariya daga kamuwa da cutar Streptococcus pneumoniae a cikin vitro da kuma a cikin jiki. Guba (PLY) da pneumococcus ke fitarwa don hana barkewar cutar Streptococcus pneumoniae. A cikin rahoton "Microbial Pathogenesis", marubucin ya nuna:

"Sakamakon ya nuna cewa quercetin yana rage yawan aikin hemolytic da kuma gubar da PLY ke haifarwa ta hanyar hana samuwar oligomers."
Bugu da ƙari, maganin quercetin zai iya rage lalacewar ƙwayoyin halitta da PLY ke haifarwa, ƙara yawan rayuwa ga beraye da suka kamu da cutar Streptococcus pneumoniae mai kisa, rage lalacewar huhu, da kuma hana cytokines (IL-1β da TNF) a cikin ruwan wanke-wanke na bronchoalveolar. -α).
Idan aka yi la'akari da muhimmancin waɗannan abubuwan da ke faruwa a cikin cututtukan cututtukan Streptococcus pneumoniae masu juriya, sakamakonmu ya nuna cewa quercetin na iya zama sabon ɗan takarar magani don maganin cututtukan pneumococcal na asibiti.
Quercetin yana yaƙi da kumburi kuma yana haɓaka aikin garkuwar jiki

Baya ga ayyukan hana ƙwayoyin cuta, quercetin kuma yana iya haɓaka garkuwar jiki da kuma yaƙi da kumburi. Wani bincike da aka buga a mujallar Nutrients a shekarar 2016 ya nuna cewa hanyoyin aiki sun haɗa da (amma ba'a iyakance ga) hana:

• Tumor necrosis factor alpha (TNF-α) wanda lipopolysaccharide (LPS) ke haifarwa a cikin macrophages. TNF-α wani cytokine ne da ke da hannu a kumburin tsarin jiki. Ana fitar da shi ta hanyar ƙwayoyin cuta masu aiki. Macrophages ƙwayoyin garkuwar jiki ne waɗanda za su iya haɗiye abubuwa na waje, ƙwayoyin cuta da sauran abubuwan da ke cutarwa ko lalacewa.
• Matakan TNF-α da interleukin (Il)-1α mRNA da lipopolysaccharide ke haifarwa a cikin ƙwayoyin glial, wanda zai iya haifar da "raguwar ƙwayoyin neuronal apoptosis"
• Hana samar da enzymes masu haifar da kumburi
• Hana sinadarin calcium shiga cikin ƙwayoyin halitta, ta haka yana hana:
◦ Sakin cytokines masu hana kumburi
◦ Kwayoyin mast na hanji suna fitar da histamine da serotonin 

A cewar wannan labarin, quercetin kuma yana iya daidaita ƙwayoyin mast, yana da aikin kariya daga ƙwayoyin cuta a cikin tsarin narkewar abinci, kuma "yana da tasiri kai tsaye kan halayen aiki na asali na ƙwayoyin rigakafi", don haka yana iya "rage ko hana hanyoyin kumburi iri-iri da ayyuka," Yana hana adadi mai yawa na abubuwan da ke haifar da ƙwayoyin cuta a cikin kewayon yawan ƙwayoyin cuta na micromolar".

Quercetin na iya zama ƙarin amfani ga mutane da yawa

Idan aka yi la'akari da fa'idodin quercetin iri-iri, yana iya zama ƙarin amfani ga mutane da yawa, ko dai matsaloli ne masu tsanani ko na dogon lokaci, yana iya yin tasiri. Wannan kuma ƙarin magani ne da nake ba da shawarar ku ajiye a cikin akwatin magani. Zai iya zama da amfani lokacin da kuka ji cewa matsalar lafiya za ta "shawo kan ku" (ko mura ce ta yau da kullun ko mura).

Idan kana da saurin kamuwa da mura da mura, za ka iya yin la'akari da shan quercetin watanni kaɗan kafin lokacin mura da sanyi don ƙarfafa garkuwar jikinka. A ƙarshe, da alama yana da amfani sosai ga marasa lafiya da ke fama da cutar metabolism, amma wauta ne a dogara kawai da wasu kari kuma a kasa magance matsaloli na asali kamar abinci da motsa jiki a lokaci guda.