Daga cikin sabbin takaddun kan wannan maganin antioxidant mai ƙarfi akwai bita da aka buga a cikin Binciken Phytotherapy a cikin Maris 2019, wanda ya sake nazarin abubuwa 9 game da tasirin quercetin akan cututtukan cututtukan da ba a sarrafa su ba.

Ciwon ƙwayar cuta yana nufin jerin matsalolin kiwon lafiya waɗanda ke ƙara haɗarin nau'in ciwon sukari na 2, cututtukan zuciya, da bugun jini, gami da hawan jini, hawan jini, matakan triglyceride, da tarin kitse.

Ko da yake cikakken bincike ya gano cewa quercetin ba shi da wani tasiri a kan azumin glucose na jini, juriya na insulin ko matakan haemoglobin A1c, ƙarin bincike na rukuni ya nuna cewa an ƙara quercetin a cikin binciken da ya ɗauki akalla 500 MG kowace rana don akalla makonni takwas. Mahimman rage yawan sukarin jinin azumi.

Quercetin yana taimakawa wajen daidaita maganganun kwayoyin halitta

A cewar wani binciken da aka buga a cikin 2016, quercetin kuma zai iya kunna tashar mitochondrial na apoptosis (mutuwar kwayar halitta da aka lalata) ta hanyar yin hulɗa tare da DNA, wanda ke haifar da sake dawowa.

Nazarin sun gano cewa quercetin na iya haifar da cytotoxicity na kwayoyin cutar sankarar bargo, kuma tasirin yana da alaƙa da kashi. Hakanan an sami ƙarancin tasirin cytotoxic a cikin ƙwayoyin kansar nono. Gabaɗaya, quercetin na iya tsawaita rayuwar berayen kansa ta sau 5 idan aka kwatanta da ƙungiyar kulawa da ba a kula da su ba.

Marubutan sun danganta waɗannan tasirin zuwa hulɗar kai tsaye tsakanin quercetin da DNA da kunnawa ta hanyar mitochondrial na apoptosis, kuma suna ba da shawarar cewa yuwuwar amfani da quercetin a matsayin maganin adjuvant don maganin ciwon daji ya cancanci ƙarin bincike.

Wani bincike na baya-bayan nan da aka buga a cikin mujallar Molecules kuma ya jaddada tasirin epigenetic na quercetin da ikonsa na:

Yin hulɗa tare da tashoshi na siginar salula
Daidaita maganganun kwayoyin halitta
Shafi ayyukan abubuwan rubutawa
Yana daidaita microribonucleic acid (microRNA)

An taɓa ɗaukar microribonucleic acid a matsayin “takarsa” DNA. Nazarin ya gano cewa DNA "takalma" ba ta da amfani. Haƙiƙa ƙaramin ƙwayoyin ribonucleic acid ne, wanda ke taka muhimmiyar rawa wajen daidaita ƙwayoyin halittar da ke yin sunadaran ɗan adam.

Ana iya amfani da microribonucleic acid azaman "canza" waɗannan kwayoyin halitta. Bisa ga shigar da microribonucleic acid, kwayar halitta na iya ɓoye kowane nau'in furotin fiye da 200. Ƙarfin Quercetin don canza microRNAs na iya yin bayanin tasirin cytotoxic da kuma dalilin da ya sa yake da alama yana ƙara tsira daga ciwon daji (akalla ga mice).

Quercetin wani sinadari ne mai ƙarfi na rigakafi

Kamar yadda aka ambata a sama, binciken da aka gudanar a kusa da quercetin yana mai da hankali kan ikon sa na rigakafi, wanda galibi saboda hanyoyin aiki guda uku:

Hana ikon ƙwayoyin cuta don harba sel
Hana kwafin ƙwayoyin cuta
Rage juriyar ƙwayoyin da suka kamu da cutar zuwa maganin ƙwayoyin cuta

Misali, wani binciken da Ma'aikatar Tsaro ta Amurka ta bayar wanda aka buga a cikin 2007 ya gano cewa bayan fuskantar matsananciyar damuwa ta jiki, quercetin na iya rage haɗarin kamuwa da cutar kuma inganta aikin tunanin ku, in ba haka ba yana iya lalata aikin rigakafin ku, Yana sa ku zama masu saurin kamuwa da cuta. zuwa cututtuka.

A cikin wannan binciken, masu hawan keke sun karɓi 1000 MG na quercetin a rana, haɗe da bitamin C (ƙaramar matakan quercetin plasma) da niacin ( haɓaka sha) tsawon makonni biyar a jere. Sakamakon ya nuna cewa idan aka kwatanta da wanda ba a kula da shi ba Ga duk wani mai keken da aka yi wa magani, waɗanda suka sha quercetin suna da ƙarancin damar kamuwa da cutar ƙwayar cuta bayan hawan keke na sa'o'i uku a rana tsawon kwanaki uku a jere. 45% na mutanen da ke cikin rukunin placebo ba su da lafiya, yayin da kawai 5% na mutanen da ke cikin rukunin jiyya ba su da lafiya.

Hukumar Binciken Cigaban Bincike ta Amurka (DARPA) ta ba da tallafin wani binciken, wanda aka buga a shekara ta 2008, kuma ta yi nazari kan amfani da kwayar cutar murar H1N1 mai saurin kamuwa da cuta don kalubalantar dabbobin da aka yi wa quercetin. Sakamakon har yanzu yana nan, rashin lafiya da mace-mace na rukunin jiyya sun kasance ƙasa da ƙasa fiye da na rukunin placebo. Sauran binciken kuma sun tabbatar da tasirin quercetin akan ƙwayoyin cuta iri-iri, gami da:

Wani bincike da aka yi a 1985 ya gano cewa quercetin na iya hana kamuwa da kamuwa da kamuwa da kamuwa da cutar ta herpes simplex nau'in 1, poliovirus type 1, parainfluenza virus type 3, da kuma numfashi syncytial virus.

Wani binciken dabba a cikin 2010 ya gano cewa quercetin na iya hana duka ƙwayoyin mura A da B. Akwai kuma manyan bincike guda biyu. Na farko, waɗannan ƙwayoyin cuta ba za su iya haɓaka juriya ga quercetin ba; na biyu, idan an yi amfani da su tare da magungunan rigakafi (amantadine ko oseltamivir), tasirin su yana inganta sosai - kuma an hana ci gaban juriya.

Wani binciken dabba a 2004 ya amince da nau'in kwayar cutar H3N2, yana binciken tasirin quercetin akan mura. Marubucin ya yi nuni da cewa:

"A lokacin kamuwa da kwayar cutar mura, damuwa na oxidative yana faruwa. Saboda quercetin na iya mayar da hankali ga yawancin antioxidants, wasu mutane suna tunanin zai iya zama magani mai mahimmanci wanda zai iya kare huhu daga fitowa a lokacin kamuwa da kwayar cutar mura. Illolin da oxygen free radicals. "

Wani bincike na 2016 ya gano cewa quercetin na iya daidaita maganganun furotin kuma yana da tasiri mai kariya akan kwayar cutar murar H1N1. Musamman, ƙa'idar furotin girgiza zafi, fibronectin 1 da furotin hanawa yana taimakawa rage kwafin ƙwayoyin cuta.

Wani bincike na uku da aka buga a cikin 2016 ya gano cewa quercetin na iya hana nau'ikan nau'ikan mura, gami da H1N1, H3N2, da H5N1. Marubucin rahoton binciken ya yi imanin, "Wannan binciken ya nuna cewa quercetin yana nuna ayyukan hanawa a farkon matakin kamuwa da mura, wanda ke ba da tsarin jiyya mai yiwuwa a nan gaba ta hanyar samar da magunguna masu inganci, masu aminci, da marasa tsada don magancewa da hana [mura. Virus] kamuwa da cuta."

A cikin 2014, masu bincike sun nuna cewa quercetin "da alama yana da alƙawarin maganin mura na yau da kullun da rhinoviruses ke haifarwa" kuma ya kara da cewa, "Bincike ya tabbatar da cewa quercetin na iya rage cikin ciki da kwafi na ƙwayoyin cuta a cikin vitro. Jiki na iya rage nauyin kwayar cutar hoto, ciwon huhu da kuma rashin amsawar hanyar iska."

Hakanan Quercetin na iya rage lalacewar iskar oxygen, ta yadda za a rage haɗarin kamuwa da cututtukan ƙwayoyin cuta na biyu, waɗanda ke haifar da mutuwar masu alaƙa da mura. Mahimmanci, quercetin yana ƙara biosynthesis na mitochondrial a cikin tsokar kwarangwal, yana nuna cewa wani ɓangare na tasirin antiviral ya kasance saboda ingantaccen siginar antiviral mitochondrial.

Wani binciken dabba a cikin 2016 ya gano cewa quercetin na iya hana cutar dengue da kamuwa da cutar hanta a cikin mice. Sauran binciken kuma sun tabbatar da cewa quercetin yana da ikon hana cututtukan hanta na B da C.

Kwanan nan, wani binciken da aka buga a cikin mujallar Microbial Pathogenesis a cikin Maris 2020 ya gano cewa quercetin na iya ba da cikakkiyar kariya daga kamuwa da cutar huhu na Streptococcus duka a cikin vitro da in vivo. Wani guba (PLY) wanda pneumococcus ya fitar don hana barkewar cutar huhu na Streptococcus. A cikin rahoton "Magungunan Kwayoyin cuta", marubucin ya nuna:

"Sakamakon ya nuna cewa quercetin yana rage yawan aikin hemolytic da cytotoxicity da PLY ta haifar ta hanyar hana samuwar oligomers.
Bugu da ƙari, maganin quercetin kuma zai iya rage lalacewa ta hanyar PLY-matsakaici, ƙara yawan rayuwa na mice da ke kamuwa da ƙwayoyin cuta na Streptococcus pneumoniae, rage lalacewar huhu, da kuma hana cytokines (IL-1β da TNF) a cikin ruwan lavage bronchoalveolar. -α) saki.
Idan akai la'akari da mahimmancin waɗannan abubuwan da suka faru a cikin pathogenesis na resistant Streptococcus pneumoniae, sakamakonmu ya nuna cewa quercetin na iya zama sabon dan takarar miyagun ƙwayoyi don maganin cututtuka na pneumococcal na asibiti. "
Quercetin yana yaki da kumburi kuma yana haɓaka aikin rigakafi

Baya ga aikin rigakafin cutar, quercetin kuma na iya haɓaka rigakafi da yaƙi kumburi. Wani bincike na 2016 da aka buga a mujallar Nutrients ya nuna cewa hanyoyin aiwatarwa sun haɗa da (amma ba'a iyakance ga) hana:

• Tumor necrosis factor alpha (TNF-α) wanda aka haifar da lipopolysaccharide (LPS) a cikin macrophages. TNF-a shine cytokine wanda ke shiga cikin kumburi na tsarin. Ana ɓoye ta ta hanyar macrophages da aka kunna. Macrophages su ne ƙwayoyin rigakafi waɗanda zasu iya haɗiye abubuwa na waje, ƙananan ƙwayoyin cuta da sauran abubuwa masu cutarwa ko lalacewa.
• Lipopolysaccharide-induced TNF-a da interleukin (Il) -1a mRNA matakan a cikin glial Kwayoyin, wanda zai iya haifar da "raguwa neuronal apoptosis"
• Hana samar da kumburin enzymes masu haifar da kumburi
Hana calcium daga kwararowa cikin sel, ta yadda zai hana:
◦ Sakin cytokines masu kumburi
◦ Kwayoyin mast na hanji suna sakin histamine da serotonin 

A cewar wannan labarin, quercetin kuma iya daidaita mast Kwayoyin, yana da cytoprotective aiki a kan gastrointestinal fili, da kuma "yana da wani kai tsaye regulatory sakamako a kan asali ayyuka halaye na rigakafi da tsarin", sabõda haka, ya iya "ƙasa-tsare ko hana iri-iri. tashoshi masu kumburi da ayyuka, "Hana babban adadin makasudin kwayoyin halitta a cikin kewayon tattarawar micromolar".

Quercetin na iya zama ƙarin amfani ga mutane da yawa

Yin la'akari da fa'idodin fa'idodin quercetin, yana iya zama ƙarin ƙarin amfani ga mutane da yawa, ko yana da matsala mai ƙarfi ko kuma na dogon lokaci, yana iya yin wani tasiri. Wannan kuma kari ne na ba da shawarar ku ajiye a cikin ma'ajin magani. Yana iya zuwa da amfani lokacin da kuka ji cewa kuna gab da samun "matsalar lafiya" ta shafe ku (ko mura ne ko mura).

Idan kana da saurin kamuwa da mura da mura, za ka iya yin la'akari da shan quercetin 'yan watanni kafin lokacin sanyi da mura don ƙarfafa tsarin rigakafi. A cikin dogon lokaci, yana da alama yana da amfani sosai ga marasa lafiya da ke fama da ciwo na rayuwa, amma yana da matukar wauta don dogara kawai ga wasu kari kuma ya kasa magance matsalolin asali kamar abinci da motsa jiki a lokaci guda.