Muna amfani da kukis don inganta ƙwarewar ku. Ta hanyar ci gaba da bincika wannan rukunin yanar gizon, kun yarda da amfani da kukis ɗinmu. Ƙarin bayani.
Ta hanyar danna "Allow All", kun yarda da adana kukis a kan na'urarku don haɓaka kewayawa ta yanar gizo, bincika amfani da shafin, da kuma tallafawa samar da abubuwan kimiyya kyauta, masu buɗewa. Ƙarin bayani.
A wani bincike da aka buga kwanan nan a mujallar Pharmaceutics, masu bincike sun gano tasirin maganin kashe ƙwayoyin cuta na wani maganin ganye mai suna FRO akan cututtukan kuraje.
Binciken ƙwayoyin cuta da kuma nazarin in vitro sun nuna cewa FRO yana da tasirin maganin kashe ƙwayoyin cuta da kuma kumburi mai yawa akan Dermatobacillus Acnes (CA), wani ƙwayar cuta da ke haifar da kuraje. Waɗannan sakamakon sun nuna aminci da amfani da shi na halitta wajen maganin kuraje, yana tallafawa amfani da madadin da ba su da guba kuma masu araha fiye da magungunan kuraje na yanzu.
Nazari: Ingancin FRO a cikin cututtukan kuraje vulgaris. Hoton da aka samo daga: Steve Jungs/Shutterstock.com
Kurajen fata, wanda aka fi sani da kurajen fata, cuta ce da ta zama ruwan dare gama gari da ke faruwa sakamakon toshewar gashin gashi tare da matattun ƙwayoyin fata. Kurajen fata suna shafar sama da kashi 80 cikin 100 na matasa, kuma duk da cewa ba sa kashe su, suna iya haifar da damuwa ta hankali, kuma a cikin mawuyacin hali, launin fata na dindindin yana bayyana da tabo.
Kuraje na faruwa ne sakamakon hulɗar kwayoyin halitta da abubuwan da suka shafi muhalli, waɗanda galibi ke faruwa ne sakamakon canje-canjen hormonal da ke tare da balaga a lokacin balaga. Waɗannan rashin daidaiton hormones suna ƙara yawan samar da sebum da kuma ƙara yawan aikin insulin growth factor 1 (IGF-1) da dihydrotestosterone (DHT).
Ana ɗaukar ƙaruwar fitar da kuraje a matsayin mataki na farko a cikin ci gaban kuraje, tunda gashin da ke cike da sebum yana ɗauke da adadi mai yawa na ƙwayoyin cuta kamar SA. SA wani sinadari ne na halitta na fata; duk da haka, ƙaruwar yaduwar phylotype IA1 yana haifar da kumburi da canza launin gashin da ke ɗauke da papules da ake iya gani a waje.
Akwai nau'ikan magungunan kwalliya daban-daban don kuraje, kamar retinoids da magungunan ƙwayoyin cuta na fata, waɗanda ake amfani da su tare da bawon sinadarai, maganin laser/light, da magungunan hormonal. Duk da haka, waɗannan magungunan suna da tsada kuma suna da alaƙa da mummunan illa.
Binciken da aka yi a baya ya binciki ruwan ganye a matsayin madadin halitta mai rahusa ga waɗannan magungunan. A madadin haka, an yi nazarin ruwan Rhus vulgaris (RV). Duk da haka, amfaninsa yana da iyaka ta urushiol, wani muhimmin sinadari mai haifar da allergies na wannan bishiyar.
FRO wani nau'in magani ne na ganye wanda ke ɗauke da ruwan 'ya'yan itace na RV (FRV) da mangosteen na Japan (OJ) a cikin rabo 1: 1. An gwada ingancin maganin ta amfani da gwaje-gwajen in vitro da kuma kaddarorin ƙwayoyin cuta.
An fara siffanta cakuda FRO ta amfani da high performance liquid chromatography (HPLC) don ware, gano da kuma ƙididdige abubuwan da ke cikinsa. An ƙara yin nazarin cakuda don samun jimlar abubuwan da ke cikin phenolic (TPC) don gano mahaɗan da suka fi iya samun kaddarorin ƙwayoyin cuta.
Gwajin ƙwayoyin cuta na farko a cikin vitro ta hanyar tantance ƙarfin yaduwar diski. Da farko, an yi wa CA (phylotype IA1) noma iri ɗaya a kan farantin agar inda aka sanya faifan takarda mai girman mm 10 na FRO da aka sanya a ciki. An tantance ayyukan ƙwayoyin cuta ta hanyar auna girman yankin da ke hana shi.
An tantance ingancin FRO akan samar da sebum da CA ke haifarwa da kuma yawan androgen da ke da alaƙa da DHT ta amfani da nazarin Oil Red da Western blot, bi da bi. Daga baya an gwada FRO don iyawarsa ta kawar da tasirin nau'in oxygen mai amsawa (ROS), waɗanda ke da alhakin hyperpigmentation da ke da alaƙa da kuraje da tabo bayan tiyata, ta amfani da binciken 2′, 7′-dichlorofluorescein diacetate (DCF-DA).
Sakamakon gwajin yaɗuwar faifan ya nuna cewa 20 μL na FRO ya yi nasarar hana ci gaban CA kuma ya samar da wani yanki mai hanawa na 13 mm a yawan 100 mg/mL. FRO yana danne ƙaruwar fitar da sinadarin sebum da SA ke haifarwa sosai, ta haka yana rage ko kuma ya mayar da faruwar kuraje.
An gano cewa FRO yana da wadataccen sinadarai masu kama da phenolic, ciki har da gallic acid, kaempferol, quercetin da fisetin. Jimlar yawan sinadarin phenolic (TPC) ya kai matsakaicin adadin 118.2 mg na gallic acid (GAE) a kowace gram FRO.
FRO ta rage kumburin ƙwayoyin halitta wanda ROS da cytokine da SA ke haifarwa ke haifarwa sosai. Rage yawan samar da ROS na dogon lokaci na iya rage yawan launin fata da tabo.
Duk da cewa akwai magungunan fata don kuraje, galibi suna da tsada kuma suna iya haifar da illoli da yawa da ba a so.
Sakamakon ya nuna cewa FRO yana da kaddarorin kashe ƙwayoyin cuta a kan CA (ƙwayoyin cuta masu haifar da kuraje), wanda hakan ke nuna cewa FRO wani madadin halitta ne, mara guba kuma mai araha ga magungunan kuraje na gargajiya. FRO kuma yana rage samar da sebum da kuma bayyanar hormones a cikin vitro, yana nuna ingancinsa wajen magancewa da hana fashewar kuraje.
Gwaje-gwajen asibiti na FRO da suka gabata sun nuna cewa mutanen da ke amfani da toner da man shafawa na FRO sun sami ci gaba mai mahimmanci a cikin sassaucin fata da matakan danshi idan aka kwatanta da ƙungiyar kulawa bayan makonni shida kacal. Duk da cewa wannan binciken bai tantance kuraje a ƙarƙashin yanayin in vitro da aka sarrafa ba, sakamakon da aka samu a yanzu ya goyi bayan bincikensu.
Idan aka haɗa waɗannan sakamakon, ana goyon bayan amfani da FRO a nan gaba a cikin magungunan kwalliya, gami da maganin kuraje da inganta lafiyar fata gaba ɗaya.
An gyara wannan labarin a ranar 9 ga Yuni, 2023 domin maye gurbin babban hoton da wanda ya fi dacewa.
An buga a: Labaran Kimiyyar Lafiya | Labaran Binciken Lafiya | Labaran Cututtuka | Labaran Magunguna
Alamu: kuraje, matasa, androgens, anti-inflammatory, cells, chromatography, cytokines, dihydrotestosterone, tasiri, fermentation, kwayoyin halitta, abubuwan girma, gashi, hormones, hyperpigmentation, in vitro, kumburi, insulin, phototherapy, liquid chromatography, oxygen, yaduwa, quercetin, retinoids, fata, ƙwayoyin fata, pigmentation fata, Western blot
Hugo Francisco de Souza marubuci ne a fannin kimiyya wanda ke zaune a Bangalore, Karnataka, Indiya. Abubuwan da yake sha'awa a fannin ilimin halittu, ilmin halittu na juyin halitta da kuma ilimin herpetology. A halin yanzu yana aiki a kan takardar digirin digirgir. daga Cibiyar Kimiyyar Muhalli a Cibiyar Kimiyya ta Indiya, inda yake nazarin asali, rarrabawa da kuma bambance-bambancen macizai masu dausayi. An ba Hugo lambar yabo ta DST-INSPIRE Fellowship saboda bincikensa na digirin digirgir da kuma lambar yabo ta Zinare daga Jami'ar Pondicherry saboda nasarorin da ya samu a fannin ilimi a lokacin karatunsa na digiri na biyu. An buga bincikensa a cikin mujallu masu tasiri da aka yi wa bita a kansu, ciki har da PLOS Neglected Tropical Diseases and Systems Biology. Lokacin da ba ya aiki da rubutu, Hugo yana kallon anime da barkwanci da yawa, yana rubutawa da kuma rubuta waƙa a gitar bass, yana yanke waƙoƙi a kan MTB, yana buga wasannin bidiyo (yana fifita kalmar "wasan"), ko kuma yana yin wasa da kusan komai. fasaha.
Francisco de Souza, Hugo. (9 ga Yuli, 2023). Hadin ganyen shuka na musamman yana ba da fa'idodi masu ƙarfi na maganin kuraje. Labarai - Likitanci. An dawo da shi ranar 11 ga Satumba, 2023, daga https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Francisco de Souza, Hugo. “Hadin ganye na musamman da aka samo daga tsirrai tare da ƙarfin maganin kuraje.” Labarai – Likita. Satumba 11, 2023.
Francisco de Souza, Hugo. “Hadin ganye na musamman da aka samo daga tsirrai tare da kyawawan kaddarorin maganin kuraje.” Labarai – Likitanci. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (An shiga Satumba 11, 2023).
Francisco de Souza, Hugo. 2023. Hadin ganyen shuka na musamman tare da kyawawan kaddarorin maganin kuraje. News Medical, an duba shi a ranar 11 ga Satumba, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Hotunan da aka yi amfani da su a cikin wannan "taƙaitaccen bayani" ba su da alaƙa da wannan binciken kuma suna ɓatar da mutane gaba ɗaya suna nuna cewa binciken ya ƙunshi gwaji a kan mutane. Ya kamata a cire shi nan take.
A wata hira da aka yi da Silvio Di Castro a taron SLAS EU na 2023 da aka yi a Brussels, Belgium, mun yi magana da Silvio Di Castro game da bincikensa da kuma rawar da yake takawa wajen kula da sinadarai a binciken magunguna.
A cikin wannan sabon shirin rediyo, Keith Stumpo na Bruker ya tattauna damarmaki daban-daban na kayayyakin halitta tare da Pelle Simpson na Enveda.
A cikin wannan hirar, NewsMedical ta yi magana da Jeff Hawkins, shugaban kamfanin Quantum-Si game da ƙalubalen hanyoyin gargajiya na proteomics da kuma yadda tsarin samar da furotin na zamani zai iya mayar da tsarin samar da furotin na dimokuradiyya.
News-Medical.Net tana ba da ayyukan bayanai na likita bisa ga waɗannan sharuɗɗa da ƙa'idodi. Lura cewa bayanan likita da ke wannan gidan yanar gizon an yi su ne don tallafawa, ba don maye gurbin dangantakar majiyyaci da likita/likita ba da kuma shawarwarin likita da za su iya bayarwa.