Muna amfani da kukis don inganta ƙwarewar ku. Ta ci gaba da bincika wannan rukunin yanar gizon, kun yarda da amfani da kukis. Karin bayani.
Ta danna "Ba da izini duka", kun yarda da adana kukis akan na'urarku don haɓaka kewayawa yanar gizo, bincika amfanin rukunin yanar gizon, da tallafawa samar da abubuwan kimiyya kyauta, buɗe ido. Karin bayani.
A cikin wani binciken da aka buga kwanan nan a cikin mujallar Pharmaceutics, masu bincike sun ƙaddara tasirin maganin ƙwayoyin cuta na wani nau'in ganye mai suna FRO akan cututtukan kuraje.
Ƙididdigar maganin ƙwayoyin cuta da bincike na in vitro ya nuna cewa FRO yana da tasiri mai mahimmanci na ƙwayoyin cuta da ƙwayoyin cuta a kan Dermatobacillus Acnes (CA), kwayar cutar da ke haifar da kuraje. Wadannan sakamakon suna nuna aminci da amfani na halitta a cikin maganin kwaskwarima na kuraje, suna tallafawa yin amfani da hanyoyin da ba mai guba ba kuma masu tsada ga magungunan kuraje na yanzu.
Nazari: Ingancin FRO a cikin cututtukan kuraje vulgaris. Hoton hoto: Steve Jungs/Shutterstock.com
Acne vulgaris, wanda aka fi sani da pimples, yanayin fata ne na yau da kullun da ke haifar da kumburin gashin gashi tare da sebum da matattun ƙwayoyin fata. Kurajen fuska na shafar fiye da kashi 80 cikin 100 na matasa kuma, ko da yake ba mai mutuwa ba ne, na iya haifar da damuwa ta tunani kuma, a lokuta masu tsanani, launin fata na dindindin da tabo.
Kurajen fuska yana fitowa ne daga cudanya da abubuwan halitta da muhalli, sau da yawa sakamakon canjin hormonal da ke tare da balaga a lokacin balaga. Wadannan rashin daidaituwa na hormonal suna haɓaka samar da sebum kuma suna ƙara haɓakar haɓakar insulin 1 (IGF-1) da aikin dihydrotestosterone (DHT).
Ƙara yawan ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ce ta haifar da ƙwayar gashi mai yawa tare da kwayoyin halitta irin su SA . SA abu ne na dabi'a na fata; duk da haka, ƙãra yaduwa na phylotype IA1 yana haifar da kumburi da pigmentation na gashin gashi tare da papules bayyane.
Akwai magunguna daban-daban na gyaran fuska ga kuraje, kamar retinoids da magungunan ƙwayoyin cuta, ana amfani da su tare da bawon sinadarai, laser / haske, da kuma abubuwan da ke haifar da hormonal. Duk da haka, waɗannan jiyya suna da tsada sosai kuma suna da alaƙa da mummunan sakamako.
Nazari na baya sun binciko tsantsar ganye a matsayin madadin halitta mai inganci mai tsada ga waɗannan jiyya. A matsayin madadin, an yi nazarin tsantsa Rhus vulgaris (RV). Duk da haka, amfani da ita yana iyakance ta urushiol, maɓalli mai mahimmanci na allergies na wannan bishiyar.
FRO wata dabara ce ta ganye mai ɗauke da haɗe-haɗe na RV (FRV) da mangosteen Jafananci (OJ) a cikin rabo 1:1. An gwada tasirin dabarar ta amfani da gwaje-gwajen in vitro da abubuwan antimicrobial.
An fara kwatanta cakudawar FRO ta amfani da babban aikin ruwa chromatography (HPLC) don keɓewa, ganowa da ƙididdige abubuwan da ke tattare da shi. An ƙara bincikar cakudar don jimlar abun ciki na phenolic (TPC) don gano mahadi masu yuwuwa suna da kaddarorin antimicrobial.
Na farko in vitro antimicrobial assay ta hanyar tantance faifan jijiya. Na farko, CA (phylotype IA1) an ƙirƙira shi daidai a kan farantin agar wanda aka sanya faifan takarda mai tacewa na mm 10 mm FRO. An kimanta aikin rigakafin ƙwayoyin cuta ta hanyar auna girman yanki mai hanawa.
An kimanta tasirin FRO akan samar da sebum mai haifar da CA da kuma haɗin gwiwar androgen da ke da alaƙa da DHT ta amfani da tabo mai jan ƙarfe da bincike na lalata ta Yamma, bi da bi. Daga baya an gwada FRO don ikonsa na kawar da tasirin nau'in oxygen mai amsawa (ROS), waɗanda ke da alhakin haɓakar kuraje masu alaƙa da hyperpigmentation da tabo bayan tiyata, ta amfani da bincike na 2′,7′-dichlorofluorescein diacetate (DCF-DA). sanadi.
Sakamakon gwajin yaduwa na faifai ya nuna cewa 20 μL na FRO ya sami nasarar hana ci gaban CA kuma ya haifar da wani yanki na hanawa na fili na 13 mm a matakin 100 mg / mL. FRO yana da matuƙar hana haɓakar sinadari na sebum da SA ke haifarwa, ta yadda hakan ke rage gudu ko kuma baya faruwar kuraje.
An gano FRO yana da wadata a cikin mahadi na phenolic ciki har da gallic acid, kaempferol, quercetin da fisetin. Jimlar phenolic fili (TPC) maida hankali ya kai 118.2 mg galic acid daidai (GAE) a kowace gram FRO.
FRO ya rage kumburin salula wanda ya haifar da ROS da SA-induced da sakin cytokine. Rage dogon lokaci a cikin samar da ROS na iya rage hyperpigmentation da tabo.
Ko da yake akwai magungunan dermatological don kuraje, yawanci suna da tsada kuma suna iya samun illoli da yawa da ba a so.
Sakamakon ya nuna cewa FRO yana da kaddarorin antibacterial akan CA (kwayoyin cuta masu haifar da kuraje), don haka yana nuna cewa FRO wata hanya ce ta halitta, marar guba kuma mai tsada ga magungunan kuraje na gargajiya. FRO kuma yana rage samar da sebum da kuma bayyanar da hormone a cikin vitro, yana nuna tasirinsa wajen magancewa da kuma hana kumburin kuraje.
Gwajin gwaji na asibiti na FRO na baya sun nuna cewa mutanen da ke amfani da toner na FRO na ci gaba da ruwan shafa sun sami ci gaba mai mahimmanci a cikin elasticity na fata da matakan danshi idan aka kwatanta da ƙungiyar kulawa bayan makonni shida kacal. Kodayake wannan binciken bai yi la'akari da kuraje a karkashin kulawa a cikin yanayin vitro ba, sakamakon yanzu yana goyan bayan binciken su.
A hade, waɗannan sakamakon suna goyan bayan amfani da FRO na gaba a cikin jiyya na kwaskwarima, gami da maganin kuraje da inganta lafiyar fata gaba ɗaya.
An gyara wannan labarin a ranar 9 ga Yuni, 2023 don maye gurbin babban hoton da mafi dacewa.
An buga a: Labaran Kimiyyar Lafiya | Labaran Bincike na Likita | Labaran Cuta | Labaran magunguna
Tags: kuraje, matasa, androgens, anti-mai kumburi, Kwayoyin, chromatography, cytokines, dihydrotestosterone, tasiri, fermentation, genetics, girma dalilai, gashi, hormones, hyperpigmentation, in vitro, kumburi, insulin, phototherapy, ruwa chromatography, oxygen, yaduwa , quercetin , retinoids, fata, fata Kwayoyin, fata pigmentation, Western blot
Hugo Francisco de Souza marubucin kimiyya ne da ke Bangalore, Karnataka, Indiya. Abubuwan sha'awar karatunsa suna cikin fagagen tarihin rayuwa, ilimin juyin halitta da ilimin herpetology. A halin yanzu yana aiki a kan takardar shaidar digirinsa. daga Cibiyar Kimiyyar Muhalli a Cibiyar Kimiyya ta Indiya, inda ya yi nazarin asali, rarrabawa da kuma kwatanta macizai. An baiwa Hugo lambar yabo ta DST-INSPIRE Fellowship saboda bincikensa na digiri na uku da kuma lambar zinare daga Jami'ar Pondicherry saboda nasarorin da ya samu a fannin ilimi a lokacin karatunsa na Master. An buga bincikensa a cikin manyan mujallun da aka yi bita na takwarorinsu ciki har da PLOS Neglected Tropical Diseases and Systems Biology. Lokacin da ba ya aiki kuma ba ya rubutu, Hugo yana bins akan ton na anime da ban dariya, ya rubuta kuma ya tsara kiɗa akan guitar bass, shreds waƙoƙi akan MTB, kunna wasannin bidiyo (ya fi son kalmar “wasan”), ko kuma tinkers tare da kusan komai. . fasaha.
Francisco de Souza, Hugo. (Yuli 9, 2023). Haɗe-haɗe na musamman na tsiro na samar da fa'idodin rigakafin kuraje masu ƙarfi. Labarai - Likita. An dawo da Satumba 11, 2023, daga https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Francisco de Souza, Hugo. "Haɗin na musamman na tsire-tsire masu ƙarfi tare da kaddarorin rigakafin kuraje." Labarai - Likita. Satumba 11, 2023.
Francisco de Souza, Hugo. "Haɗin na musamman na tsire-tsire masu ƙarfi tare da kaddarorin rigakafin kuraje." Labarai - Likita. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (An shiga Satumba 11, 2023).
Francisco de Souza, Hugo. 2023. A musamman saje na shuka tsantsa tare da iko anti-kuraje Properties. Labaran Likitanci, an shiga Satumba 11, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Hotunan da aka yi amfani da su a cikin wannan "takaice" ba su da alaƙa da wannan binciken kuma suna da cikakkiyar kuskure wajen nuna cewa binciken ya ƙunshi gwaji akan mutane. Ya kamata a cire shi nan da nan.
A cikin wata hira da aka yi a taron SLAS EU 2023 a Brussels, Belgium, mun yi magana da Silvio Di Castro game da bincikensa da kuma rawar da ke tattare da sarrafa magunguna a cikin binciken harhada magunguna.
A cikin wannan sabon faifan podcast, Bruker's Keith Stumpo yayi magana game da damammaki masu yawa na samfuran halitta tare da Enveda's Pelle Simpson.
A cikin wannan hirar, NewsMedical yayi magana da Shugaban Kamfanin Quantum-Si Jeff Hawkins game da ƙalubalen hanyoyin gargajiya ga ilimin ƙwayoyin cuta da kuma yadda tsarin furotin na gaba zai iya daidaita tsarin tsarin furotin.
News-Medical.Net yana ba da sabis na bayanin likita bisa waɗannan sharuɗɗa da sharuɗɗan. Lura cewa bayanin likita akan wannan gidan yanar gizon an yi niyya ne don tallafawa, kuma ba maye gurbin, alaƙar likita da likita ba da shawarar likita da zasu iya bayarwa.