Ƙarin da ake kira 5-hydroxytryptophan (5-HTP) ko osetriptan ana ɗaukarsa ɗaya daga cikin madadin maganin ciwon kai da ƙaura.Jiki yana canza wannan abu zuwa serotonin (5-HT), wanda kuma aka sani da serotonin, wani neurotransmitter wanda ke daidaita yanayi da zafi.
Ana ganin ƙananan matakan serotonin a cikin mutanen da ke da damuwa, amma masu fama da ciwon kai da masu fama da ciwon kai na iya samun ƙananan matakan serotonin a lokacin da tsakanin hare-haren.Ba a san dalilin da yasa ake danganta migraines da serotonin ba.Shahararriyar ka'idar ita ce rashi na serotonin yana sa mutane su damu da jin zafi.
Saboda wannan haɗin, hanyoyi da yawa na ƙara yawan aikin serotonin a cikin kwakwalwa ana amfani da su akai-akai don hana migraines da kuma magance mummunan hare-hare.
5-HTP amino acid ne wanda jiki ya yi daga mahimman amino acid L-tryptophan kuma dole ne a samo shi daga abinci.Ana samun L-tryptophan a cikin abinci irin su tsaba, waken soya, turkey da cuku.Enzymes a dabi'a suna canza L-tryptophan zuwa 5-HTP, wanda ke canza 5-HTP zuwa 5-HT.
5-HTP kari ana yin su ne daga shukar magani na yammacin Afirka Griffonia simplicifolia.An yi amfani da wannan ƙarin don magance bakin ciki, fibromyalgia, ciwo na gajiya mai tsanani, da kuma asarar nauyi, amma babu wani tabbataccen shaida na amfanin sa.
Lokacin yin la'akari da 5-HTP ko kowane kari na halitta, yana da mahimmanci a fahimci cewa waɗannan samfuran sunadarai ne.Idan kun ɗauke su saboda suna da ƙarfi don yin tasiri mai kyau akan lafiyar ku, ku tuna cewa suma suna iya zama masu ƙarfi don samun mummunan tasiri.
Ba a sani ba ko abubuwan 5-HTP suna da amfani ga migraines ko wasu nau'in ciwon kai.Gabaɗaya, bincike yana da iyaka;wasu nazarin sun nuna yana taimakawa, yayin da wasu ba su nuna wani tasiri ba.
Nazarin Migraine sunyi amfani da allurai na 5-HTP daga 25 zuwa 200 MG kowace rana a cikin manya.A halin yanzu babu takamaiman ko shawarar sashi don wannan ƙarin, amma yana da kyau a lura cewa yawancin allurai suna da alaƙa da illa da hulɗar miyagun ƙwayoyi.
5-HTP na iya yin hulɗa da wasu magunguna, ciki har da carbidopa, wanda ake amfani da shi don magance cutar Parkinson.Hakanan yana iya yin hulɗa tare da triptans, SSRIs, da monoamine oxidase inhibitors (MAOIs, wani nau'in antidepressants).
Tryptophan da 5-HTP kari na iya zama gurbata tare da na halitta sashi 4,5-tryptophanione, wani neurotoxin kuma aka sani da Peak X. The kumburi effects na Peak X iya haifar da tsoka zafi, cramping, da zazzabi.Sakamakon dogon lokaci na iya haɗawa da tsoka da lalacewar jijiya.
Domin wannan sinadari ya samo asali ne daga wani sinadari ba najasa ko gurbacewa ba, ana iya samunsa a cikin kari ko da an shirya shi a cikin yanayin tsafta.
Yana da mahimmanci a tattauna shan duk wani kari tare da likitan ku ko likitan magunguna don tabbatar da cewa sun kasance lafiya a gare ku kuma ba za su yi hulɗa da sauran magungunan ku ba.
Ka tuna cewa kayan abinci na abinci da na ganye ba su yi nazari mai tsauri da gwaji iri ɗaya ba kamar yadda ake yin amfani da magunguna da magunguna, ma'ana binciken da ke goyan bayan tasiri da amincin su yana da iyaka ko bai cika ba.
Kari da magungunan dabi'a na iya zama abin sha'awa, musamman idan ba su da illa.A gaskiya ma, magungunan halitta sun tabbatar da tasiri ga cututtuka da yawa.Akwai shaida cewa abubuwan da ake amfani da su na magnesium na iya rage yawan mita da tsanani na hare-haren ƙaura.Duk da haka, ba a sani ba ko 5-HTP yana da amfani ga migraines.
Horvath GA, Selby K, Poskitt K, et al.’Yan’uwan da ke da ƙananan matakan sinadarai na sinadarai suna haɓaka migraines hemiplegic, seizures, spastic paraplegia na ci gaba, yanayin yanayi, da kuma suma.Ciwon kai.2011;31 (15): 1580-1586.Lambar: 10.1177/0333102411420584.
Aggarwal M, Puri V, Puri S. Serotonin da CGRP a cikin migraines.Ann Neuroscience.2012;19 (2):88–94.doi:10.5214/ans.0972.7531.12190210
Chauvel V, Moulton S, Chenin J. Sakamakon Estrogen-Estrogen na 5-hydroxytryptophan akan yada damuwa na cortical a cikin berayen: yin samfurin hulɗar serotonin da hormone ovarian a cikin migraine aura.Ciwon kai.2018;38 (3): 427-436.Lambar: 10.1177/0333102417690891
Victor S., Ryan SV Magunguna don rigakafin migraine a cikin yara.Cochrane Database Syst Rev 2003; (4): CD002761.Lambar: 10.1002/14651858.CD002761
Das YT, Bagchi M., Bagchi D., Preus HG Tsaro na 5-hydroxy-L-tryptophan.Haruffa akan toxicology.2004; 150 (1): 111-22.doi:10.1016/j.toxlet.2003.12.070
Teri Robert Teri Robert marubuci ne, malami mai haƙuri, kuma mai ba da shawara ga masu haƙuri ƙware a cikin ƙaura da ciwon kai.